About the laboratory

The research field of the Brain Plasticity laboratory is the study of the molecular, cellular, anatomical and behavioral mechanisms of neuroplasticity. This theme is addressed by an integrated multidisciplinary approach, combining genetics, molecular and cellular biology, neural network studies, brain imaging, physiology and behavior.

Our laboratory brings together researchers interested in understanding the functioning of the brain at different scales, in order to develop collaborations and synergies. Complementary biological models are studied, namely the isolated nerve cell (Zsolt Lenkeï’s team), the brain of the Drosophila (Thomas Preat’s team and Serge Birman’s team), the brain of mammals (Karim Benchenane’s team and Sophie Pezet’s team), and the human brain (François Vialatte’s team).

The unique situation of the Brain Plasticity laboratory, within ESPCI Paris, allows us to develop unusual and fruitful bridges between neurobiology and physics.

In the light and continuity of the study of basic mechanisms of neuroplasticity, our projects include, concretely or potentially, applications to human cerebral pathology. We are interested in certain neurological or psychiatric conditions such as the effects of cannabinoids on memory or major psychiatric illnesses (depression, schizophrenia) (Zsolt Lenkei’s team and Karim Benchenane’s team), understanding neuronal mechanisms involved in sleep physiology (Karim Benchenane’s team), neuropathic pain (Sophie Pezet’s team) or studying Genetic models in Drosophila, molecular mechanisms involved in Parkinson’s disease (Serge Birman’s team), and Alzheimer’s disease (Thomas Preat’s team and François Vialatte’s team). The applied nature of this work, particularly in physics and neuropathology, suggests that they may lead to valuations at the industrial level (brain-computer interface, caracterisation of molecules).

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Practical Information

Unit Director Thomas Preat Administrators Bernadett Chamard Stéphanie Ledoux Tu-Khanh Nguyen Phone : +33 (0) 1 40 79 43 02 To contact (...) 

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Drosophila Clock is required in brain pacemaker neurons to prevent premature locomotor aging independently of its circadian function

Vaccaro A., Issa A.-R., Seugnet L., Birman S.* & Klarsfeld A.* PLOS Genetics (2017). 13(1):e1006507. Abstract Circadian clocks control many (...) 

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Practical information

Unit Director
Thomas Preat
thomas.preat (arobase) espci.fr

Administrators
Bernadett Chamard
bernadett.chamard (arobase) espci.fr

Stéphanie Ledoux
stephanie.ledoux (arobase) espci.fr

Tu-Khanh Nguyen
tu-khanh.nguyen (arobase) espci.fr

Phone : +33 (0) 1 40 79 43 02

To contact us