Editorial

About the laboratory

The research field of the Brain Plasticity laboratory is the study of the molecular, cellular, anatomical and behavioral mechanisms of neuroplasticity. This theme is addressed by an integrated multidisciplinary approach, combining genetics, molecular and cellular biology, neural network studies, brain imaging, physiology and behavior.

Our laboratory brings together researchers interested in understanding the functioning of the brain at different scales, in order to develop collaborations and synergies. Complementary biological models are studied, the brain of the Drosophila (Thomas Preat & Pierre-Yves Plaçais’s team and Serge Birman’s team), the brain of mammals (Karim Benchenane’s team, Sophie Pezet’s team and Gisella Vetere’s team), and the human brain.

The unique situation of the Brain Plasticity laboratory, within ESPCI Paris, allows us to develop unusual and fruitful bridges between neurobiology and physics.

In the light and continuity of the study of basic mechanisms of neuroplasticity, our projects include, concretely or potentially, applications to human cerebral pathology. We are interested in certain neurological or psychiatric conditions such as the effects of cannabinoids on memory or major psychiatric illnesses (Karim Benchenane’s team), understanding neuronal mechanisms involved in sleep physiology (Karim Benchenane’s team), neuropathic pain (Sophie Pezet’s team), understanding neural codes and brain plasticity underlying memory processes (Gisella Vetere’s team) or studying Genetic models in Drosophila, molecular mechanisms involved in Parkinson’s disease (Serge Birman’s team), and Alzheimer’s disease (Thomas Preat & Pierre-Yves Plaçais’s team). The applied nature of this work, particularly in physics and neuropathology, suggests that they may lead to valuations at the industrial level (brain-computer interface, caracterisation of molecules).



News

Each year, the Jeunes Talents France program...

Each year, the Jeunes Talents France program rewards 35 talented women scientists at the PhD and post-doctoral levels. Lauren Reynolds, a post-doctoral fellow in the Neurophysiology and Behavior team (led by Philippe Faure and Alexandre Mourot) is one of the winners.

Karim BENCHENANE : ERC Consolidator Grant 2016

Karim BENCHENANE, Head of the Memory, Oscillations and Brain States team is the recipient of an ERC Consolidator Grant that supports ambitious projects. He is encouraged for his work on the manipulation of memories of aversive experiences during sleep via a brain-machine interface (MNEMOSYNE Project).

Gisella Vetere : Head of a the new Team C4

Gisella VETERE, Professor at ESPCI Paris, is heading a new team of the Brain Plasticity Unit, C4 (Cerebral Codes and Circuits Connectivity) from August 2018. Her group will study the neural mechanisms governing memory acquisition and consolidation in mice and how these processes change the neural plasticity.

Thomas PREAT: ERC Advanced Grant 2016

Thomas PREAT, Head of the Energy & Memory team, is the recipient of an ERC Advanced Grant. This attribution confirms his position as a leader in the field of memory neurobiology. His EnergyMemo project focuses on the integrated physiological study in drosophila of the interplay between energy metabolism and long-term memory.

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Recent publications

Drosophila Middle-Term Memory: Amnesiac is Required for PKA Activation in the Mushroom Bodies, a Function Modulated by Neprilysin 1

J Neurosci 2020 May 20;40(21):4219-4229
Oriane Turrel, Yasmine Rabah, Pierre-Yves Plaçais, Valérie Goguel, Thomas Preat
Abstract
In Drosophila, the mushroom bodies (MB) constitute the central brain ... (...)


Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice

Nature Communications volume 12, Article number: 6945 (2021)
Malou Dongelmans, Romain Durand-de Cuttoli, Claire Nguyen, Maxime Come, Etienne K. Duranté, Damien Lemoine, Raphaël Brito, Tarek Ahmed... (...)


An inhibitory hippocampal–thalamic pathway modulates remote memory retrieval

Nat Neurosci 2021 May;24(5):685-693.
Gisella Vetere, Frances Xia, Adam I Ramsaran, Lina M Tran, Sheena A Josselyn, Paul W Frankland.
Abstract
Memories are supported by distributed hippocampal-thalamic... (...)


Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety

Neuron (2021) Aug 18;109(16):2604-2615.
Claire Nguyen, Sarah Mondoloni , Tinaïg Le Borgne , Ines Centeno , Maxime Come, Joachim Jehl, Clément Solié, Lauren M Reynolds, Romain Durand-de Cuttoli,... (...)


Memory formation in the absence of experience.

Nat Neurosci (2019) 933-940.
Vetere G, Tran LM, Moberg S, Steadman PE, Restivo L, Morrison FG, Ressler KJ, Josselyn SA, Frankland PW.
Abstract
Memory is coded by patterns of neural activity in... (...)


> More publications...

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Practical information

Unit Director
Thomas PREAT
thomas.preat (arobase) espci.fr

Administrator
Tu-Khanh NGUYEN
tu-khanh.nguyen (arobase) espci.fr
Elisa SILVEIRA
elisa.silveira (arobase) espci.fr

Phone : +33 (0) 1 40 79 43 02

To contact us