Publications since 1998

    • Silva B, Mantha OL, Schor J,Pascual A, Plaçais PY, Pavlowsky A* , Preat T* (2022) Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Nature Metabolism 4(2):213–224 . * :co-senior authors
    • de Tredern E§, Rabah Y§, Pasquer L, Minatchy J, Plaçais PY*, Preat T.* Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory. Cell Rep. 24;36(8):109620. * :co-senior authors
    • Hadjieconomou D, King G, Gaspar P, Mineo A, Blackie L, Ameku T, Studd C, de Mendoza A, Diao F, White BH, Brown AEX, Plaçais PY, Preat T, Miguel-Aliaga I. (2020) Enteric neurons increase maternal food intake during reproduction. Nature. 587(7834):455-459.
    • Turrel O, Rabah Y, Plaçais PY, Goguel V, Preat T. (2020) Drosophila Middle-Term Memory: Amnesiac is Required for PKA Activation in the Mushroom Bodies, a Function Modulated by Neprilysin 1. J Neurosci. 20;40(21):4219-4229.
    • Hudry B., de Goeij E., Mineo A., Gaspar P., Hadjieconomou D., Studd C., Mokochinski J.B., Kramer H.B., Plaçais P.-Y., Preat T., Miguel-Aliaga I. (2019). Sex differences in intestinal carbohydrate metabolism promote food intake and sperm maturation. Cell. 178: 901-918.
    • Dolan M.J., Belliart-Guérin G., Bates A.S., Frechter S., Lampin-Saint-Amaux A., Aso Y., Roberts R.J.V, Schlegel P., Wong A., Hammad A., Bock D., Rubin G.M., Preat T., Plaçais P.-Y.*, Jefferis G.S.X.E.* (2018). Communication from Learned to Innate Olfactory Processing Centers Is Required for Memory Retrieval in Drosophila. Neuron. 100: 651-668. * :co-senior authors
    • Turrel O., Goguel V. and Preat T. (2018). Amnesiac is required in the adult mushroom body for memory formation. J. Neurosci. 38: 9202-9214.
    • Pavlowsky, A., Schor, J., Plaçais P.-Y. and Preat, T. (2018). A GABAergic feedback shapes dopaminergic input on the Drosophila mushroom body to promote appetitive long-term memory. Curr. Biol. 28: 1-11.
    • Scheunemann, L., Plaçais, P.-Y., Dromard, Y., Schwärzel, M. and Preat, T. (2018). Dunce phosphodiesterase acts as a checkpoint for drosophila long-term memory in a pair of serotonergic neurons. Neuron. 98: 350-365.
    • Musso, P.-Y., Lampin-Saint-Amaux, A., Tchenio, P. and Preat,T. (2017). Ingestion of artificial sweeteners leads to caloric frustration memory in Drosophila. Nat. Commun. 8(1):1803.
    • Turrel, O., Goguel, V.* and Preat, T.* (2017). Drosophila neprilysin 1 rescues memory deficits caused by amyloid-β peptide. J Neurosci, 37: 10334-10345. *: co-senior authors.
    • Plaçais, P.-Y.*, de Tredern, E., Scheunemann, L., Trannoy, S., Goguel, V., Han, K.-A., Isabel, G., and Preat, T.* (2017). Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory. Nat Commun, 8:15510. *co-senior authors.
    • Turrel, O., Lampin-Saint-Amaux, A., Preat, T. and Goguel, V. (2016). Drosophila neprilysins are involved in middle-term and long-term memory. J Neurosci, 36: 9535–9546.
    • Bouzaiane, E., Trannoy, S., Scheunemann, L., Plaçais, P.-Y*. and Preat, T.* (2015). Two independent mushroom body output circuits retrieve the six discrete components of Drosophila aversive memory. Cell Rep, 11: 1-13. *: co-senior authors.
    • Musso, P.-Y., Tchenio, P. and Preat, T. (2015). Delayed dopamine signaling of energy level builds appetitive long-term memory in Drosophila. Cell Rep, 10: 1-9.
    • Bourdet, I., Preat, T. and Goguel, V. (2015). The Full-Length Form of the Drosophila Amyloid Precursor Protein Is Involved in Memory Formation. J Neurosci, 35(3): 1043–1051.
    • Yamagata, N., Ichinose, T., Aso, Y., Plaçais, P.-Y., Friedrich, A.B., Sima, R.J., Preat, T., Rubin, G.M. and Tanimoto, H. (2015). Distinct dopamine neurons mediate reward signals for short- and long-term memories. Proc Natl Acad Sci USA, 112(2): 578-83.
    • Aso, Y., Sitaraman, D., Ichinose, T., Kaun, K., Vogt, K., Belliart-Guérin, G., Plaçais, P.-Y., Robie, A., Yamagata, N., Schnaitmann, C., Rowell, W., Johnston, R., Ngo, T., Chen, N., Korff, W., Nitabach, M., Heberlein, U., Preat, T., Branson, K., Tanimoto, H. and Rubin G. (2014). Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila. eLife, 3: e04580.
    • Leforestier, A., Levitz, P., Preat, T., Guttmann, P., Michot, L. J. and Tchenio, P. (2014). Imaging Drosophila brain by combining cryo-soft X-ray microscopy of thick vitreous sections and cryo-electron microscopy of ultrathin vitreous sections. J Struct Biol. 188: 177-182.
    • Masson, A., Pedrazzani, M., Benrezzak, S., Tchenio, P., Preat, T. and Nutarelli, D. (2013). Micromirror structured illumination microscope for high-speed in vivo drosophila brain imaging. Optics Express. 22(2): 1243-1256.
    • Plaçais, P.-Y., Trannoy, S., Friedrich, A. B., Tanimoto, H. and Preat, T. (2013). Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. Cell Rep 5: 769-780.
    • Plaçais, P.-Y. and Preat, T. (2013). To favor survival under food shortage, the brain disables costly memory. Science, 339(6118): 440-442.
    • Le Glou E., Seugnet L., Shaw P.J., Preat T. and Goguel V. (2012). Circadian modulation of consolidated 
memory retrieval following sleep deprivation in Drosophila. Sleep, 35(10): 1377-1384
    • Lagasse F., Moreno C., Preat T. and Mery F. (2012). Functional and evolutionary trade-offs co-occur between two consolidated memory phases in Drosophila melanogaster. Proc Biol Sci, 279(1744) : 4015-4023.
    • Redt-Clouet C., Trannoy S., Boulanger A., Tokmatcheva E., Savvateeva-Popova E., Parmentier M.-L., Preat T. * and Dura J.-M.* (2012) (*co-corresponding). Mushroom body neuronal remodelling is necessary for short-term but not for long-term courtship memory in Drosophila. Eur J Neurosci, 35(11) : 1684-1691.
    • Liu, C., Plaçais, P.-Y., Yamagata, N., Pfeiffer, B.D., Aso, Y., Friedrich, A.B., Siwanowicz, I., Rubin, G.M., Preat, T. and Tanimoto H. (2012). A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature, 488(7412) : 512-516.
    • Plaçais, P.-Y., Trannoy, S., Isabel, G., Aso, Y., Siwanowicz, I., Belliart-Guérin, G., Vernier, P., Birman, S., Tanimoto, H. and Preat, T. (2012). Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila. Nat Neurosci, 15(4) : 592-599.
    • Kottler, B., Lampin-Saint-Amaux, A., Comas, D., Preat, T.* and Goguel, V.* (2011) (*co-corresponding). Debra, a protein mediating lysosomal degradation, is required for long-term memory in drosophila. PLoS One, 6(10) : e25902.
    • Trannoy, S., Redt-Clouet, C., Dura, J.-M.* and Preat, T.* (2011) (*co-corresponding). Parallel processing of appetitive short- and long-term memories in Drosophila. Curr Biol, 21(19) : 1647-1653.
    • Séjourné, J., Plaçais, P.-Y., Aso, Y., Siwanowicz, I., Trannoy, S., Vladimiros, T., Tedjakumala, S.R., Rubin, G.M., Tchénio, P., Ito, K., Isabel, G., Tanimoto, H.* and Preat, T.* (2011) (* co-corresponding). Mushroom body efferent neurons responsible for aversive olfactory memory retrieval in Drosophila. Nat Neurosci, 14(7) : 903-910.
    • Copf T., Goguel V., Lampin-Saint-Amaux A., Scaplehorn N. and Preat T. (2011). Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. Proc Natl Acad Sci USA, 108(19) : 8059-8064.
    • Goguel, V., Belair, A.-L., Ayaz, D., Lampin-Saint-Amaux, A., Scaplehorn, N., Hassan, B.A. and Preat, T. (2011). Drosophila Amyloid Precursor Protein-Like is required for long-term memory. J Neurosci, 31(3) : 1032-1037.
    • Riemensperger, T., Isabel, G., Coulom, H., Neuser, K., Seugnet, L., Kume, K., Iché-Torres, M., Cassar, M., Strauss, R., Preat, T., Hirsh, J., and Birman, S. (2011). Behavioral consequences of dopamine deficiency in the Drosophila central nervous system. Proc Natl Acad Sci USA, 108(2) : 834-839.
    • Yuan, C., Rao, R.P., Jesmin, N., Bamba, T., Nagashima, K., Pascual, A., Preat, T., Fukusaki, E., Acharya, U. and Acharya., J. K. (2011). CDase is a pan-ceramidase in Drosophila. Mol Biol Cell, 22(1) : 33-43.
    • Chabaud, M.-A., Preat, T.* and Kaiser, L.* (2010) (* co-corresponding). Behavioral characterization of individual olfactory memory retrieval in Drosophila melanogaster. Frontiers Behav Neurosci, 4 : 12-22.
    • Gervasi, N., Tchénio, P. and Preat, T. (2010). PKA dynamics in a Drosophila learning center : coincidence detection by Rutabaga adenylyl cyclase and spatial regulation by Dunce phosphodiesterase. Neuron, 65(4) : 516-529.
    • Chabaud, M.-A., Isabel, G., Kaiser, L. and Preat, T. (2009). Social facilitation of long-lasting memory retrieval in Drosophila. Curr Biol, 19(19) : 1654-1659.
    • Colomb J., Kaiser L., Chabaud M.-A. and Preat T. (2009). Parametric and genetic analysis of drosophila appetitive long-term memory and sugar motivation. Genes Brain Behav, 8(4) : 407-415.
    • Preat, T. and Isabel, G. (2008). Molecular and system analysis of olfactory memory in drosophila. In « Learning and Memory : A Comprehensive Reference ». Elsevier. Ed J.H. Byrne.
    • Milhiet, E., Comas, D., Richard, A., Didelot, G., Débarre, A., Preat, T. and Tchénio, P. (2007). A new in-situ hybridization towards single-RNA detection. J of Luminescence, 127(1) : 276-279.
    • Preat, T., Da Lage, J.-L., Didelot G., Molinari F., Tchénio P., Milhiet E., Munnich A., Colleaux L., Cariou, M.-L. (2007). Response to comment on “Tequila, A Neurotrypsin Ortholog, Regulates Long-Term Memory Formation In Drosophila”. Science, 316 : 1698c.
    • Comas, D., Isabel, I. and Preat, T. (2007). A new era for drosophila learning and memory studies. "Neurobehavioral Genetics". In Neurobehavioral Genetics : Methods and Application (CRC Press), 2nd Edition. Eds B.C. Jones and P. Mormède. pp. 333-352.
    • Kawecki T. J., Pont J., Preat T., Mery F. (2007). Experimental Evolution of Olfactory Memory in Drosophila melanogaster. Physiol Biochem Zool, 80(4) : 399-405.
    • Chabaud M.A., Devaud J.-M., Pham-Delegue M.-H., Preat T. and Kaiser L. (2006). Olfactory conditioning of proboscis activity in Drosophila melanogaster. J Comp Physiol A, 192(12) : 1335-48.
    • Didelot G., Molinari F., Tchenio P., Comas D., Milhiet E., Munnich A., Colleaux L. and Preat T. (2006). Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila. Science, 313(5788) : 851-853.
    • Aguda A.H., Xue B., Irobi E., Preat T. and Robinson R.C. (2006). The Structural Basis of Actin Interaction with Multiple WH2/beta-Thymosin Motif-Containing Proteins. Structure, 14(3) : 469-76.
    • Leonard R., Rendic D., Rabouille C., Wilson I.B., Preat T. and Altmann F. (2006). The Drosophila fused lobes gene encodes an N-acetylglucosaminidase involved in N-glycan processing. J Biol Chem, 281(8) : 4867-75.
    • Nicolas, E. and Preat, T. (2005). Drosophila central brain formation requires Robo proteins. Dev Genes Evol, 215(10) : 530-6.
    • Pascual, A., Chaminade, M. and Preat, T. (2005). Ethanolamine kinase controls neuroblast divisions in Drosophila mushroom bodies. Dev Biol, 280(1) : 177-186.
    • Pascual, A., Huang, K.-L. and Preat, T. (2005). Conditional UAS-targeted repression in Drosophila. Nuc Ac Res, 2005 33(1) : e7.
    • Perazzona, B., Isabel, G., Preat, T. and Davis R.L. (2004). The Role of CREB in Drosophila Long-Term Memory. J Neurosci, 24(40) : 8823-8828.
    • Comas, C., Petit, F. and Preat, T. (2004). Regulation of cathepsin activity is involved in Drosophila long-term memory formation. Nature, 430 : 460-463.
    • Edward Ryder, Fiona Blows, Michael Ashburner, Rosa Bautista-Llacer, Darin Coulson, Jenny Drummond, Jane Webster, David Gubb, Nicola Gunton, Glynnis Johnson, Cahir O’Kane, David Huen, Punita Sharma, Zoltan Asztalos, Heiko Baisch, Janet Schulze, Maria Kube, Kathrin Kittlaus, Gunter Reuter, Peter Maroy, Janos Szidonya, Åsa Rasmuson-Lestander, Karin Ekström, Barry Dickson, Christoph Hugentobler, Hugo Stocker, Ernst Hafen, Jean Antoine Lepesant, Gert Pflugfelder, Martin Heisenberg, Bernard Mechler, Florenci Serras, Montserrat Corominas, Stephan Schneuwly, Thomas Preat, John Roote and Steven Russell (2004). The DrosDel collection : a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics, 167(2) : 797-813.
    • Hertzog M., Didry D., van Heijenoort C., Gaudier M., Coutant J., Gigant B., Didelot G., Preat T., Knossow M., Guittet E. and Carlier M. (2004). The ß-thymosin / wh2 domain : structural basis for the switch from inhibition to promotion of actin assembly. Cell, 117(5) : 611-23.
    • Preat., T. (2004). Diverse mechanisms to remember various odors. Neuron, 44(3) : 404-5.
    • Isabel, G. Pascual, A. and Preat, T. (2004). Exclusive consolidated memory phases in Drosophila. Science, 304:1024-1027.
    • Pascual A., Huang K., Neveu, J. and Preat T. (2004). Brain asymmetry and long-term memory. Nature, 247(6975) : 605-606.
    • Kamyshev N.G., Iliadi K.G., Bragina J.V., Kamysheva E.A., Tokmatcheva E.V., Preat T. and Savvateeva-Popova E.V. (2002). Novel memory mutants in Drosophila : Behavioral characteristics of the mutant nemyP153. BMC Neuroscience, 3(1) : 9.
    • Moreau-Fauvarque C., Taillebourg E., Preat T. and Dura J.-M. (2002). Mutation of linotte causes behavioral defects independently of pigeon in Drosophila. Neuroreport, 13(17) : 2309-12.
    • Pascual A. and Preat T. (2001). Localization of long-term memory within the Drosophila mushroom body. Science, 294 : 1115-1117.
    • Hitier R., Chaminade M. and Preat T. (2001). The Drosophila castor gene is involved in postembryonic brain development. Mech Dev, 103(1-2) : 3-11.
    • Blanchardon E., Grima B., Klarsfeld A., Chélot A., Hardin P. E., Preat T., and Rouyer F. (2001). Defining the role of Drosophila lateral neurons in the control of circadian activity and eclosion rhythms by targeted genetic ablation and PERIOD protein overexpression. Eur J Neurosci, 13(5) : 888-891.
    • Hitier R., Simon A., Savarit F. and Preat T. (2000). no-bridge and linotte act jointly at the interhemispheric junction to build up the adult central brain of Drosophila melanogaster. Mech Dev, 99 : 93-100.
    • Kamyshev N.G, Iliadi K.G., Bragina Y.V., Savvateeva-Popova E.V., Tokmacheva E.V. and Preat T. (2000). Identification of Drosophila mutants with memory defects after acquisition of conditioned reflex suppression of courtship. Neuroscience Behavior and Physiology, 30(3) : 307-13.
    • Boquet I., Boujemaa R., Carlier M.-F. and Preat T. (2000). Ciboulot regulates actin assembly during Drosophila brain metamorphosis. Cell, 102 : 797-808.
    • Boquet I., Hitier R., Dumas M., Chaminade M. and Preat T. (2000). Central brain postembryonic development in Drosophila : implication of genes expressed at the interhemispheric junction. J Neurobiol, 42 : 33-48.
    • Preat T. (1999). Testing associative learning in Drosophila. in Handbook of Molecular-Genetic Techniques for Brain and Behavior Research. Elsevier Science. Eds W. Crusio and R. Gerlaï.
    • Preat T. (1998). Decreased odor avoidance after electric shock in Drosophila mutants biases learning and memory tests. J Neurosci, 18(20) : 8534-8538.
    • Simon A., Boquet I., Synguélakis M. and Preat T. (1998). The Drosophila putative kinase Linotte (Derailed) prevents central brain axons from converging on a newly described interhemispheric ring. Mech Dev, 76(1-2) : 45-55.
    • Hitier R., Heisenberg M. and Preat T. (1998). Abnormal mushroom body plasticity in the memory mutant amnesiac. Neuroreport, 9(12) : 2717-2719.

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Team

Thomas PREAT and Pierre-Yves PLAÇAIS are jointly heading the team "Energy & Memory". Tenured Researchers Thomas PREAT Group leader, (...) 

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Thomas Preat

2012 | Equipe membre de l’ENP (Ecole des Neurosciences de Paris Ile-de-France) 2012 | Thomas Preat membre de l’EMBO Equipe membre du Labex « (...) 

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Practical information

Unit Director
Thomas PREAT
thomas.preat (arobase) espci.fr

Deputy Director
Philippe FAURE
philippe.faure (arobase) espci.fr

Administrator
Hélène Geoffroy
helene.geoffroy (arobase) espci.fr

Jeldy Cubas Hernandez
jeldy.cubas-hernandez (arobase) espci.fr

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